Skin Rejuvenation with a Biomimetic Peptide Designed to Promote Desquamation
D. Schmid, E. Belser, Ch. Liechti, F. Zuelli
SÖFW-Journal 132 (3): 2 - 6 (2006)
In old skin the turnover time of the epidermis is increased and desquamation is not homogeneous anymore leading to dry, rough and scaly skin. Desquamation requires the degradation of connections between corneocytes that are formed by cell adhesion proteins. A short protein sequence, called cell adhesion recognition (CAR) site, is essential to hold the cells together. A peptide containing the CAR sequence was designed in order to compete with cell to cell binding and thus to promote desquamation. Tested in a placebo-controlled human study, the peptide was found to reduce the epidermal turnover time to values typical for young skin. This kind of peeling effect resulted in secondary skin benefits such as significantly increased smoothness, reduces wrinkle depth and increased hydration.
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D. Schmid, E. Belser, Ch. Liechti, F. Zuelli
SÖFW-Journal 132 (3): 2 - 6 (2006)
In old skin the turnover time of the epidermis is increased and desquamation is not homogeneous anymore leading to dry, rough and scaly skin. Desquamation requires the degradation of connections between corneocytes that are formed by cell adhesion proteins. A short protein sequence, called cell adhesion recognition (CAR) site, is essential to hold the cells together. A peptide containing the CAR sequence was designed in order to compete with cell to cell binding and thus to promote desquamation. Tested in a placebo-controlled human study, the peptide was found to reduce the epidermal turnover time to values typical for young skin. This kind of peeling effect resulted in secondary skin benefits such as significantly increased smoothness, reduces wrinkle depth and increased hydration.
download pdf
